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My publications Publications DOI: The aim of this work was to investigate whether raspberry consumption can improve vascular function and to understand which phenolic metabolites may be responsible for the effects.
A 3 arm double-blind randomized controlled crossover human intervention trial was conducted in 10 healthy males. The role of physicomechanical factors that may induce EMP release in vivo is still unknown. We studied the relationship of EMPs and physicomechanical factors in stable arterial hypertension and hypertensive emergencies, and investigated the pattern of EMP release after mechanical endothelial injury.
Besides blood pressure measurements, pulse-wave-analysis was performed.
Flow-mediated dilation FMD Single frauen buhl, nitroglycerin-mediated dilation NMDand wall-shear-stress WSS were measured ultrasonographically in the brachial artery; microvascular perfusion by laser-Doppler Clinicaltrials.
Graphical abstract In arterial hypertension, increased systolic blood pressure and decreased wall shear stress due to greater arterial diameter are associated with the release of endothelial microparticles EMPs. EMPs may be part of a vicious self-perpetuating cycle involving endothelial dysfunction.
Chronic mesenteric ischemia CMI is caused by stenosis or occlusion of the celiac trunk, superior mesenteric artery or inferior artery. In conclusion, the risk factors are smoking, arterial hypertension, dyslipidemia and old age.
Women are more affected than men. The most commonly affected is the tunic coeliacus. Diet-related disorders along with malnutrition but appetite and abdominal flow noise may be important clinical indications of CMI that should lead to a duplex ultrasound examination and functional examinations in a specialized center.
To plan further procedures, CT angiography may be necessary. The treatment of choice of symptomatic CMI, especially in multivessel disease, is revascularization. In most cases, because of low post-interventional mortality in mostly multimorbid patients and excellent clinical and technical success rates, endovascular procedures are preferred.
As with CHD and PAOD, lifestyle modification and optimal drug therapy with statins and aspirin should be used to reduce risk in patients with atherosclerosis of the mesenteric arteries, but studies in this patient population do not exist.
After revascularization, platelet inhibition is indicated. Herz- und Kreislaufforschung e.
Das vorgeschlagene Vorgehen ergibt sich aus der wissenschaftlichen Evidenz, wobei randomisierte, kontrollierte Studien bevorzugt werden.
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